AI & Medicine, as an important division of Protheragen, is a company that combines AI and biophysics for drug research and development. Our expert team focuses on the development of macromolecular drugs in the field of tumor immunotherapy. The team has carried out research in the computational immunology laboratory and has a background in physical chemistry, machine learning, and immunology.
Neoantigens are newly formed antigens that have not been previously recognized by the immune system. Neoantigens can arise from altered tumor proteins formed as a result of tumor mutations or from viral proteins. It could be specifically recognized by neoantigen-specific T cell receptors (TCRs) in the context of major histocompatibility complexes (MHCs) molecules. Neoantigen is an ideal immunotherapy target because they are distinguished from germline and could be recognized as non-self by the host immune system.
The current model of AI new drug research and development is to find a certain protein produced by gene mutations. However, we may find that each patient has a different mutation site of tumor gene, resulting in displaying different neoantigen on the tumor cell surface.
It is time-consuming and laborious for researchers to verify the gene mutation site and the corresponding neoantigen. Currently, the development of gene mutation technology makes it possible to quickly and effectively screen neoantigens of each patient individually, which lays the foundation for the clinical application of neoantigen vaccines.
Figure 1 Flowchart for tumor neoantigen prediction and detection of T cell–recognized neoantigens (Jiang, T., Shi, T., Zhang, H. et al. 2019)
Our self-developed AI macromolecular drug research and development platform has been applied to three sub-fields of drug design:
AI can be used to guide high-throughput experiments and more conducive to the development of new drug.
Judging from the current talent composition of the company, more team members come from the Department of Biology, Chemistry, Computational Biology, etc.
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