About 20%-30% of genes in the genome of organisms encode membrane proteins. Membrane proteins play a key role in a variety of cellular functions, such as ligand-receptor binding, signal transduction, molecular transport, intercellular recognition, and cellular adhesion and so on. At present, in the fields of biological research and drug development, there is an increasing demand for membrane proteins as targets. The successful preparation of membrane protein is an important prerequisite for obtaining powerful anti-membrane protein antibodies. Since most membrane proteins are partially or completely embedded in the lipid bilayer, conventional protein expression methods may have some obstacles in the preparation of membrane proteins, such as low expression levels, relatively difficult extraction, possible misfolding, and incomplete translation after modification and so on.
Figure 1. Member prorein.
MedAI can provide you with professional membrane protein construction services:
|Project name||Membrane Protein Modeling Service|
Because there are too few membrane receptor proteins with known three-dimensional structures, structures based on knowledge modeling are unreliable and subjective. With the accumulation of membrane protein structure data and the improvement of computer modeling methods, computational modeling will inevitably become more mature, and the construction of 3D structures will be more reliable. Once the three-dimensional structure model of the membrane receptor protein is obtained, it can be further inverted to guide experimental research, such as receptor site mutation and drug design based on receptor structure. Our advantage:
|Cycle||Depends on the time you need to simulate and the time required for the system to reach equilibrium.|
|Product delivery mode||The simulation results provide you with the raw data and analysis results of molecular dynamics.|
MedAI's membrane protein modeling service can reduce the cost of subsequent experiments. Membrane protein modeling service is a personalized and customized innovative scientific research service. Before determining the corresponding analysis plan and price, each project needs to be evaluated. If you want to know more about service prices or technical details, please feel free to contact us. If you want to know more about service prices or technical details, please feel free to contact us.
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