Homology modeling, also known as protein comparative modeling, refers to the construction of an atomic resolution model of the "target" protein based on its "amino acid" sequence and the experimental three-dimensional structure ("template") of the related homologous protein. Homology modeling relies on the identification of a more known protein structure or a structure that may be similar to the query sequence, and the alignment in production. The study of mapping residues in the query sequence to residues in the template sequence shows that the Among homologs, protein structures are more conserved than protein sequences, but sequences with less than 20% sequence identity may have very different structures. Evolutionary related proteins have similar sequences, while naturally occurring homologous proteins have similar protein structures. It has been shown that three-dimensional protein structures are evolutionarily more conservative than expected based solely on sequence conservation. The sequence alignment and template structure are then used to generate a structural model of the target. Because protein structures are more conserved than DNA sequences, a detectable level of sequence similarity usually implies significant structural similarity. The quality of the homology model depends on the quality of the sequence alignment and template structure.
MedAI provides high-quality homology modeling services. The results can help researchers understand the structural characteristics of the target protein, analyze its "structure-function" relationship, and can be used for drug screening, discover potential disease treatment drugs or study the interaction between the target and the drug. The homology modeling process can be divided into seven consecutive steps:
|Project name||Homology Modeling Service|
|Cycle||Depends on the time you need to simulate and the time required for the system to reach equilibrium.|
|Product delivery mode||The simulation results provide you with the raw data and analysis results of molecular dynamics.|
MedAI's homology modeling service can reduce the cost of subsequent experiments. Homology modeling service is a personalized and customized innovative scientific research service. Before determining the corresponding analysis plan and price, each project needs to be evaluated. If you want to know more about service prices or technical details, please feel free to contact us. If you want to know more about service prices or technical details, please feel free to contact us.
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