Fusion protein refers to a new type of protein produced by fusing the Fc segment of immunoglobulin (lgG, lgA, etc.) with a certain biologically active functional protein molecule using genetic engineering technology. Functional proteins with biological activity can be cellular FDF factors, toxins, receptors, enzymes, antigen peptides and the like. The fusion protein can not only exert the biological activity of the fusion protein, but also has some antibody properties, such as antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity. Guided phagocytosis (ADCP) and so on. Protein drugs have a short half-life in plasma. In order to achieve therapeutic effects, large doses are required, which will cause serious side effects and cause a huge burden on patients. The fusion of functional protein with the Fc segment of immunoglobulin can prolong the half-life of the drug in plasma and reduce the immunogenicity of the drug, which is of great significance in the diagnosis and treatment of diseases.
Figure 1. Fusion protein.
MedAI's structural modeling program requires the selection of two protein components to be fused, the structure of which is known, or the use of appropriately selected templates for computational modeling.Then, the connection between the two fusion partners and the federation or domain insertion strategy are used to create the initial fusion model. The final model is generated by calculating the conformation of the region bridging the fusion partner, so that the protein domains are moved, rotated and interacted to achieve a stable conformation. The construction of the fusion protein is divided into the following five steps:
|Project name||Fusion Protein Modeling Service|
|Cycle||Depends on the time you need to simulate and the time required for the system to reach equilibrium.|
|Product delivery mode||The simulation results provide you with the raw data and analysis results of molecular dynamics.|
MedAI's fusion protein modeling service can reduce the cost of subsequent experiments. Fusion protein modeling service is a personalized and customized innovative scientific research service. Before determining the corresponding analysis plan and price, each project needs to be evaluated. If you want to know more about service prices or technical details, please feel free to contact us. If you want to know more about service prices or technical details, please feel free to contact us.
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