Introduction of EpiXcan Based Analysis
EpiXcan, which uses a Bayesian hierarchical model, tries to optimize the weaknesses of PrediXcan by applying epigenetic annotations to optimize the weights assigned to cis-eQTL and improve the predictability of gene expression levels. It is a novel method that increses prediction accuracy in transcriptome imputation by integrating epigenetic data to model the prior probability that a SNP affects transcription.
The principle of EpiXcan analysis is to integrate biological related data into a framework (such as leverages epigenetic annotation to inform transcriptomic imputation) to improve the performance of gene expression prediction. The specific analysis steps are as follows:
Fig 1. Comparison of gene-trait associations between EpiXcan and PrediXcan. (Zhang W, et al. 2019)
Transcriptome-wide association studies (TWAS) integrate gene expression data with common risk variation to identify gene-trait associations. Since TWAS is limited to genes that can be accurately predicted from genotype data, many downstream analyses are restricted. The analysis method of EpiXcan can improve the accuracy of prediction, thereby increasing the scope and ability of analysis. Overall, EpiXcan method utilizes epigenomic information to further improve prediction of transcriptomes and it provides a framework for TWASs, improving interrogation of traitassociated biological pathway involvement, and a platform for drug utilization and treatment development.
MedAI uses EpiXcan, which uses a Bayesian hierarchical model, to improve the accuracy of genes that predicted from tanscriptome-wide association studies data. With the help of Bayesian genetic models, EpiXcan has more power to detect significant genes, including novel and unique associations, which are indispensable for life and clinically significant. For tanscriptome-wide association studies data analysis, we provide different analysis method such as EpiXcan and PrediXcan according to your needs. In addition, with the help of artificial intelligence methods, we provide a one-stop biological data analysis service. You only need to provide the original data, and we will provide you with complete results reports and charts. Regarding data analysis, if you have any questions, please feel free to contact us. Sincerely at your service.
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